Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 111

年份

2024 1

2023 6

2022 8

2021 6

2020 3

2019 12

2018 6

2017 13

2016 3

2015 3

2014 1

2013 7

2012 1

2011 4

2010 7

2009 7

2008 3

2007 8

2006 4

2005 1

展开︾

关键词

模糊优选 2

盾构选型 2

选址 2

选型 2

2035年 1

AHP法 1

BP神经网络 1

IgG 1

N-糖基心血管年龄 1

SNP芯片 1

TOPSIS法 1

三塔悬索桥 1

三峡工程 1

上海港 1

中长期水文智能预报 1

井身结构 1

产业变革 1

优化 1

优化设计 1

展开︾

检索范围：

排序：展示方式：

Everyone has a donor: contribution of the Chinese experience to global practice of haploidentical hematopoietic

Meng Lv, Yingjun Chang, Xiaojun Huang

《医学前沿（英文）》 2019年第13卷第1期页码 45-56 doi: 10.1007/s11684-017-0595-7

摘要： Human leukocyte antigen (HLA)-matched donors for hematopoietic stem cell transplantation (HSCT) have long been scarce in China. Haploidentical (haplo) donors are available for the vast majority of patients, but toxicity has limited this approach. Three new approaches for haplo-HSCT originated from Italy, China, and USA in 1990 and have been developed to world-renowned system up to now. The Chinese approach have been greatly improved by implementing new individualized conditioning regimens, donor selection based on non-HLA systems, risk-directed strategies for graft-versus-host disease and relapse, and infection management. Haplo-HSCT has exhibited similar efficacy to HLA-matched HSCT and has gradually become the predominant donor source and the first alternative donor choice for allo-HSCT in China. Registry-based analyses and multicenter studies adhering to international standards facilitated the transformation of the unique Chinese experience into an inspiration for the refinement of global practice. This review will focus on how the new era in which “everyone has a donor” will become a reality in China.

关键词： haploidentical hematopoietic stem cell transplantation conditioning graft-versus-host disease relapse infection donor selection

HTML PDF 收藏

The influence of brain death on donor liver and the potential mechanisms of protective intervention

null

《医学前沿（英文）》 2011年第5卷第1期页码 8-14 doi: 10.1007/s11684-011-0109-y

摘要：

Brain-dead donors have become one of the main sources of organs for transplantation in Western countries. The quality of donor organs is closely related to the outcome of the transplantation. Experimental studies have confirmed the inferior graft survival of livers from brain-dead donors compared with those from living donors. Studies conducted in the past 10 years have shown that brain death is associated with effects on the decreased donor organ quality. However, whether the decrease in the viability of donor organs is caused by brain death or by the events before and after brain death remains uncertain. The purpose of this review is to introduce the advances and controversies regarding the influence of brain death on the viability of donor livers and to summarize the mechanisms of the different protective interventions for donor livers.

关键词： brain death donor liver

HTML PDF 收藏

Regulation of radicals by hydrogen-donor solvent in direct coal liquefaction

《化学科学与工程前沿（英文）》 2022年第16卷第12期页码 1689-1699 doi: 10.1007/s11705-022-2186-7

摘要： Radicals are important intermediates in direct coal liquefaction. Certain radicals can cause the cleavage of chemical bonds. At high temperatures, radical fragments can be produced by the splitting of large organic molecules, which can break strong chemical bonds through the induction pyrolysis of radicals. The reaction between the formation and annihilation of coal radical fragments and the effect of hydrogen-donor solvents on the radical fragments are discussed in lignite hydrogenolysis. Using the hydroxyl and ether bonds as indicators, the effects of different radicals on the cleavage of chemical bond were investigated employing density functional theory calculations and lignite hydrogenolysis experiments. Results showed that the adjustment of the coal radical fragments could be made by the addition of hydrogen-donor solvents. Results showed that the transition from coal radical fragment to H radical leads to the variation of product distribution. The synergistic mechanism of hydrogen supply and hydrogenolysis of hydrogen-donor solvent was proposed.

关键词： direct coal liquefaction hydrogen-donor solvent induced pyrolysis radical mechanism density functional theory calculations

HTML PDF 收藏

Enhanced photoelectrochemical water splitting with a donor-acceptor polyimide

《能源前沿（英文）》 doi: 10.1007/s11708-023-0910-8

摘要： Polyimide (PI) has emerged as a promising organic photocatalyst owing to its distinct advantages of high visible-light response, facile synthesis, molecularly tunable donor-acceptor structure, and excellent physicochemical stability. However, the synthesis of high-quality PI photoelectrode remains a challenge, and photoelectrochemical (PEC) water splitting for PI has been less studied. Herein, the synthesis of uniform PI photoelectrode films via a simple spin-coating method was reported, and their PEC properties were investigated using melamine as donor and various anhydrides as acceptors. The influence of the conjugate size of aromatic unit (phenyl, biphenyl, naphthalene, perylene) of electron acceptor on PEC performance were studied, where naphthalene-based PI photoelectrode exhibited the highest photocurrent response. This is resulted from the unification of wide-range light absorption, efficient charge separation and transport, and strong photooxidation capacity. This paper expands the material library of polymer films for PEC applications and contributes to the rational design of efficient polymer photoelectrodes.

关键词： polyimide (PI) film photoelectrochemistry band structure engineering aromatic unit

HTML PDF 收藏

used as a salvage option for patients with relapsed acute leukemia post-chemotherapy plus modified donor

《医学前沿（英文）》 2021年第15卷第5期页码 728-739 doi: 10.1007/s11684-021-0833-x

摘要： Relapse is the main problem after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The outcome of a second allo-HSCT (HSCT2) for relapse post-HSCT has shown promising results in some previous studies. However, little is known about the efficacy of HSCT2 in patients with relapsed/refractory acute leukemia (AL) post-chemotherapy plus modified donor lymphocyte infusion (post-Chemo+m-DLI) after the first allo-HSCT (HSCT1). Therefore, we retrospectively analyzed the efficacy of HSCT2 in 28 patients with relapsed/refractory AL post-Chemo+m-DLI in our center. With a median follow-up of 918 (457–1732) days, 26 patients (92.9%) achieved complete remission, and 2 patients exhibited persistent disease. The probabilities of overall survival (OS) and disease-free survival (DFS) 1 year after HSCT2 were 25.0% and 21.4%, respectively. The cumulative incidences of nonrelapse mortality on day 100 and at 1 year post-HSCT2 were 7.1%±4.9% and 25.0%±8.4%. The cumulative incidences of relapse were 50.0%±9.8% and 53.5%±9.9% at 1 and 2 years post-HSCT2, respectively. Risk stratification prior to HSCT1 and percentage of blasts before HSCT2 were independent risk factors for OS post-HSCT2, and relapse within 6 months post-HSCT1 was an independent risk factor for DFS and relapse post-HSCT2. Our findings suggest that HSCT2 could be a salvage option for patients with relapsed AL post-Chemo+m-DLI.

关键词： second hematopoietic stem cell transplantation acute leukemia relapse chemotherapy modified donor lymphocyte infusion

HTML PDF 收藏

Review on ranking and selection: A new perspective

L. Jeff HONG, Weiwei FAN, Jun LUO

《工程管理前沿（英文）》 2021年第8卷第3期页码 321-343 doi: 10.1007/s42524-021-0152-6

摘要： In this paper, we briefly review the development of ranking and selection (R&S) in the past 70 years, especially the theoretical achievements and practical applications in the past 20 years. Different from the frequentist and Bayesian classifications adopted by Kim and Nelson (2006b) and Chick (2006) in their review articles, we categorize existing R&S procedures into fixed-precision and fixed-budget procedures, as in Hunter and Nelson (2017). We show that these two categories of procedures essentially differ in the underlying methodological formulations, i.e., they are built on hypothesis testing and dynamic programming, respectively. In light of this variation, we review in detail some well-known procedures in the literature and show how they fit into these two formulations. In addition, we discuss the use of R&S procedures in solving various practical problems and propose what we think are the important research questions in the field.

关键词： ranking and selection hypothesis testing dynamic programming simulation

HTML PDF 收藏

Control mode selection for modal control of long-span arch bridge

Zhengying LI, Zhengliang LI,

《结构与土木工程前沿（英文）》 2009年第3卷第4期页码 401-406 doi: 10.1007/s11709-009-0052-z

摘要： For seismic control of arch bridge, a model reduction of long-span arch bridge was implemented based on modal analysis. As for the critical mode selection, an approach based on the maximum modal displacement was presented. This approach takes into consideration the effect of external seismic excitation and is more reasonable than only considering dynamic bridge characteristics based on a modal contribution ratio. The time domain and frequency domain analysis method were used to verify the simplified model of the Nimu arch bridge in Tibet as an example. The numerical results show that the method of maximal modal displacement better analyze long-span arch bridge when multisupport seismic excitation must be considered. The reduced-order system also is more in line with the performance of the original model.

关键词： selection reduced-order excitation long-span simplified

HTML PDF 收藏

leukemia/myelodysplastic syndrome with unsatisfactory response to minimal residual disease-directed donor

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

《医学前沿（英文）》 2019年第13卷第2期页码 238-249 doi: 10.1007/s11684-017-0599-3

摘要： The efficacy of salvage interferon-α (IFN-α) treatment was investigated in patients with unsatisfactory response to minimal residual disease (MRD)-directed donor lymphocyte infusion (DLI) ( =24). Patients who did not become MRD-negative at 1 month after DLI were those with unsatisfactory response and were eligible to receive salvage IFN-α treatment within 3 months of DLI. Recombinant human IFN-α-2b injections were subcutaneously administered 2–3 times a week for 6 months. Nine (37.5%), 6 (25.0%), and 3 (12.5%) patients became MRD-negative at 1, 2, and>2 months after the salvage IFN-α treatment, respectively. Two-year cumulative incidences of relapse and non-relapse mortality were 35.9% and 8.3%, respectively. Two-year probabilities of event-free survival, disease-free survival, and overall survival were 51.6%, 54.3%, and 68.0%, respectively. Outcomes of patients subjected to salvage IFN-α treatment after DLI were significantly better than those with persistent MRD without IFN-α treatment. Moreover, clinical outcomes were comparable between the salvage DLI and IFN-α treatment groups. Thus, salvage IFN-α treatment may help improve the outcome of patients with unsatisfactory responses to MRD-directed DLI and could be a potential salvage treatment for these patients after allogeneic hematopoietic stem cell transplantation.

关键词： interferon-α hematopoietic stem cell transplantation minimal residual disease donor lymphocyte infusion

HTML PDF 收藏

Supplier selection and order splitting in multiple-sourcing inventory systems

WANG Guicong, JIANG Zhaoliang, LI Zhaoqian, LIU Wenping

《机械工程前沿（英文）》 2008年第3卷第1期页码 23-27 doi: 10.1007/s11465-008-0016-3

摘要： Supplier selection and inventory control are critical decision processes in single-item multiple-supplier systems. An integer linear programming model is proposed to help managers determine the reorder level, choose the best suppliers, and place the optimum order quantities so that the total average inventory cost is minimum, and constraints of supplier ability, quality, and demand are considered. An algorithm combining the branch-bound algorithm and enumeration algorithm is developed to solve the problems. Application of the proposed model in an automobile industry shows that it is effective.

关键词： automobile industry branch-bound algorithm selection single-item multiple-supplier effective

HTML PDF 收藏

Partial liver transplantation

null

《医学前沿（英文）》 2011年第5卷第1期页码 1-7 doi: 10.1007/s11684-010-0105-7

摘要：

Partial liver transplantation, including reduced-size liver transplantation, split liver transplantation, and living donor liver transplantation, has been developed with several innovative techniques because of donor shortage. Reduced-size liver transplantation is based on Couinaud’s anatomical classification, benefiting children and small adult recipients but failing to relieve the overall donor shortage. Split liver transplantation provides chances to two or even more recipients when only one liver graft is available. The splitting technique must follow stricter anatomical and physiological criteria either ex situ or in situto ensure long-term quality. The first and most important issue involving living donor liver transplantation is donor safety. Before surgery, a series of donor evaluations—including anatomical, liver volume, and liver function evaluations—is indispensable, followed by ethnic agreement. At different recipient conditions, auxiliary liver transplantation and auxiliary partial orthotopic liver transplantation, which employ piggyback techniques, are good alternatives. Partial liver transplantation enriches the practice and knowledge of the transplant society.

关键词： partial liver transplantation reduced-size liver transplantation split liver transplantation living donor liver transplantation

HTML PDF 收藏

Genomic regions under selection for important traits in domestic horse breeds

Xuexue LIU, Yuehui MA, Lin JIANG

《农业科学与工程前沿（英文）》 2017年第4卷第3期页码 289-294 doi: 10.15302/J-FASE-2017155

摘要： Horses were domesticated 5500 years ago, thousands of years later than other domestic animals; however, in this relatively short period, domestic horses have had a great impact on human history by accelerating civilization, revolutionizing warfare and advancing agricultural production. Modern breeding using marker-assisted selection has greatly accelerated breeding progress. Therefore, identification of genetic markers underlying the traits of interest in domestic horses is the basis for the modern breeding system. In this review, we present an overview of genetic mapping studies and genome wide analyses to identify the genomic regions targeted by positive selection for four important aspects of horses, coat color, racing performance, gait and height at withers. The locus, for example, has been shown to be the main gene responsible for chestnut color, and the locus has been shown to control the muscle fiber growth in racing breeds. The missense mutation in is the causal mutation for the alternate gaits in horses. Height at withers, a quantitative trait, was mapped to four major loci (3:105547002, 6:81481064, 9:75550059 and 11:232597 32) that can explain 83% of the height variations in domestic horses.

关键词： horse coat color racing performance gait height

HTML PDF 收藏

patients receiving haploidentical allografts and those receiving human leukocyte antigen-matched sibling donor

null

《医学前沿（英文）》 2018年第12卷第2期页码 153-163 doi: 10.1007/s11684-017-0548-1

摘要：

To establish optimal reference values for recovered immune cell subsets, we prospectively investigated post-transplant immune reconstitution (IR) in 144 patients who received allogeneic stem cell transplantation (allo-SCT) and without showing any of the following events: poor graft function, grades II?IV acute graft-versus-host disease (GVHD), serious chronic GVHD, serious bacterial infection, invasive fungal infection, or relapse or death in the first year after transplantation. IR was rapid in monocytes, intermediate in lymphocytes, CD3⁺ T cells, CD8⁺ T cells, and CD19⁺ B cells, and very slow in CD4⁺ T cells in the entire patient cohort. Immune recovery was generally faster under HLA-matched sibling donor transplantation than under haploidentical transplantation. Results suggest that patients with an IR comparable to the reference values display superior survival, and the levels of recovery in immune cells need not reach those in healthy donor in the first year after transplantation. We suggest that data from this recipient cohort should be used as reference values for post-transplant immune cell counts in patients receiving HSCT.

关键词： immune reconstitution hematopoietic stem cell transplantation event-free patients reference range

HTML PDF 收藏

Acid Orange 7 degradation using methane as the sole carbon source and electron donor

《环境科学与工程前沿（英文）》 2022年第16卷第3期 doi: 10.1007/s11783-021-1468-5

摘要：

• AO7 degradation was coupled with anaerobic methane oxidation.

关键词： Azo dyes AO7 degradation Anaerobic methane oxidation Microbial community ANME-2d

HTML PDF 收藏

“机械灌注+”应用于扩大标准供肝移植——肝尽其用 Review

王周城, Jack Martin, 余炯杰, 汪恺, Kourosh Saeb-Parsy, 徐骁

《工程（英文）》 2024年第32卷第1期页码 30-41 doi: 10.1016/j.eng.2023.11.003

摘要：

移植是终末期肝病最有效的治疗方法，但由于供体器官的短缺而受到限制。扩大标准供体（ECD）供肝在临床实践中越来越多地用于缓解这一挑战。然而，这些移植物耐受缺血的能力下降，危及冷保存期间器官的活力。机器灌注（MP）旨在改善器官保存并减少移植后并发症。然而，越来越明显的是，单独使用MP无法达到ECD供肝的最佳保存。因此，人们逐渐开始重视改良的 MP 策略，包括使用不同的灌注剂、改良的灌注方式并结合不同的治疗干预策略。本文中，我们提出了“机械灌注+”的新理念，代表这些旨在提升器官功能并可能实现ECD供肝体外再生的机械灌注新策略。为此，我们总结了现有和改良的MP策略，并阐述其在临床场景中修复不同ECD供肝的优势。

关键词：肝移植扩大标准供体机械灌注+ 器官短缺

HTML PDF 收藏

Case-based reasoning for selection of the best practices in low-carbon city development

Zhenhua HUANG, Hongqin FAN, Liyin SHEN

《工程管理前沿（英文）》 2019年第6卷第3期页码 416-432 doi: 10.1007/s42524-019-0036-1

摘要： Cities emit extensive carbon emissions, which are considered a major contributor to the severe issue of climate change. Various low-carbon development programs have been initiated at the city level worldwide to address this problem. These practices are invaluable in promoting the development of low-carbon cities. Therefore, an effective approach should be developed to help decision makers select the best practices from previous experience on the basis of the impact features of carbon emission and city context features. This study introduces a case-based reasoning methodology for a specific city to select the best practices as references for low-carbon city development. The proposed methodology consists of three main components, namely, case representation, case retrieval, and case adaption and retention. For city representation, this study selects city context features and the impact features of carbon emission to characterize and represent a city. The proposed methodology is demonstrated by applying it to the selection of the best practices for low-carbon development of Chengdu City in Sichuan Province, China.

关键词： low-carbon city carbon emission best practices case-based reasoning